LeSS (Large Scale Scrum) has been used for a dozen, hundreds, and thousands of people. If you're willing to work at it, you can simplify your organization, increase your adaptability to changing business conditions, and liberate your developers by removing unnecessary process and hierarchy. See http://less.works or https://www.amazon.com/Large-Scale-Scrum-More-Addison-Wesley-Signature/dp/0321985710 for more information. (v5.1)