0:00 Introduction
0:17 Topic of Discussion (MHC)
0:31 Notes on MHC - 1
0:49 Classification of MHC in Organisms
1:00 MHC
1:12 Notes on MHC - 2
1:23 Role Of MHC in Immune System
2:05 Notes of MHC - 3
2:20 Main Function Of MHC
2:46 Notes on MHC -4
2:54 Epitope
3:10 Notes on MHC - 5
3:28 Subdivision of MHC
3:34 MHC 1
3:49 MHC 2
4:02 MHC 3
4:28 Notes on MHC - 6
4:44 Conclusion

In this presentation, we will discuss the major histocompatibility complex or otherwise called MHC. It is a very important part of the immune system, so understanding of MHC is very important to understand the concepts of the immune system.

MHC is a set of genes that is the part of our DNA that encodes a specific protein. Question is what kinds of protein MHC encodes.

MHC encodes cell surface proteins essential for the immune system to recognize foreign molecules. This recognition determines the compatibility of cells towards each other. It is also known as histocompatibility. Histo -means tissue and compatibility mean when two things are able to exist or occur together without problems or conflict. In simple words these proteins help the cells to recognize the difference between self and non-self. Therefore, MHC determines the compatibility of donors for organ transplants, as well as susceptibility to autoimmune disease.

The main function of MHC molecules is to bind to proteins derived from pathogens and display them on the cell surface for recognition by the appropriate immune cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells.
Each MHC molecule on the cell surface displays a molecular fraction of a protein, called an epitope. The presented antigen can be either self or non-self, thus preventing an organism's immune system targeting its own cells.

The MHC gene family is divided into three subgroups: MHC class I, MHC class II, and MHC class III. Class, I MHC molecules have β2 microglobulin subunit which can only be recognized by CD8 co-receptors. Therefore they bind with the cells that express CD8 co-receptors. Class II MHC molecules have β1 and β2 subunits and can be recognized by CD4 co-receptors. Therefore they bind with the cells that express CD4 co-receptors.

MHC class III is poorly defined structurally and functionally. They are not involved in antigen binding. Only a few of them are actually involved in immunity while many are signaling molecules that play a role in cell communications. They are mainly known from their genes because their gene cluster is present between those of class I and class II.

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