0:00 Introduction
0:22 Importance
0:43 Classification
1:04 Role
1:22 Other Name
1:29 Determination
1:47 Main function
1:57 Interaction
2:07 Epitope
2:26 Sub-Groups
2:35 MHC Class 1
2:50 MHC Class 2
3:07 MHC Class 3
3:32 Conclusion
3:53 Coming soon

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Major Histocompatibility Complex (MHC) introduction | MHC Class-1, 2, 3 | | Basic Science
Series
In this presentation, we will focus on the structure and function of major histocompatibility complex class-1 molecules in detail. We will also know about the interaction with CD 8 co-receptor and the function of various domains of MHC class-1 molecule. So please watch the full presentation to understand the structure and functions of the MHC class-1 molecule.

Definition: The Major Histocompatibility Complex (MHC), also known as the Human Leukocyte Antigen (HLA) system in humans, is a group of genes that encode cell surface proteins responsible for presenting antigens to the immune system.

Genetic locus: The MHC is located on chromosome 6 in humans and is highly polymorphic, meaning it exhibits extensive genetic variation between individuals.

Types of MHC molecules: There are two main classes of MHC molecules: MHC class I and MHC class II.

MHC class I molecules: MHC class I molecules are expressed on the surface of almost all nucleated cells in the body. They present antigens derived from intracellular pathogens, such as viruses and some bacteria, to cytotoxic T cells (CD8+ T cells).

MHC class II molecules: MHC class II molecules are primarily expressed on the surface of antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells. They present antigens derived from extracellular pathogens to helper T cells (CD4+ T cells).

Antigen presentation: MHC molecules bind to antigens, which are fragments of proteins from pathogens, and display them on the cell surface. This process is known as antigen presentation.

Recognition by T cells: T cells have receptors called T cell receptors (TCRs) that can recognize specific antigens displayed by MHC molecules. CD8+ T cells recognize antigen-MHC class I complexes, while CD4+ T cells recognize antigen-MHC class II complexes.

Role in immune response: MHC molecules play a crucial role in the adaptive immune response by allowing T cells to recognize and respond to foreign antigens. They are essential for the activation and coordination of immune cells during infection or other immune challenges.

MHC polymorphism: The MHC genes are highly polymorphic, meaning there are many different versions or alleles of these genes within a population. This polymorphism allows for a wide range of antigen presentation and enhances the immune system's ability to recognize a diverse array of pathogens.

Transplantation compatibility: MHC compatibility is a critical factor in organ and tissue transplantation. The recipient's immune system must be compatible with the MHC molecules of the donor to avoid rejection of the transplanted tissue.

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