Depression is one of the most common mood disorders worldwide and can affect anyone regardless of age and sex. This brings us to fluoxetine – an antidepressant that has potential to be a cutting edge treatment for depression and other mental disorders. This video covers topics of depression, general information regarding fluoxetine (e.g., side effects, dosage), as well as the biological mechanism of the fluoxetine and how it is used to combat depression.

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This video is provided for general and educational information only. Please consult your health care provider for Information about your health.

This video was made by McMaster students Amelinda Firdauzy, Michelle Huynh, Noah Stancati in collaboration with the McMaster Demystifying Medicine Program

Copyright McMaster University 2020

#DemystifyingMedicine, #MentalHealth

References:

Arroll, B. et al.. (2005). Efficacy and Tolerability of Tricyclic Antidepressants and SSRIs Compared With Placebo for Treatment of Depression in Primary Care: A Meta-Analysis. The Annals of Family Medicine, 3(5), 449–456.

Brigitta, B. (2002). Pathophysiology of depression and mechanisms of treatment. Dialogues in Clinical Neuroscience, 4(1), 7–20.

Bromet, E., et al. (2011). Cross-national epidemiology of DSM-IV major depressive episode. BMC Medicine, 9(1), 90.

Depression. (n.d.). Retrieved October 29, 2020, from https://www.who.int/news-room/fact-sheets/detail/depression

Fava, M., Rosenbaum, J. F. et al. (2000). Fluoxetine versus sertraline and paroxetine in major depression: Tolerability and efficacy in anxious depression. Journal of Affective Disorders, 59(2), 119–126.

Ferguson, J. M. (2001). SSRI Antidepressant Medications: Adverse Effects and Tolerability. The Primary Care Companion to The Journal of Clinical Psychiatry, 03(01), 22–27.

Furukawa, et al. (2019). Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: A systematic review and dose-response meta-analysis. The Lancet Psychiatry, 6(7), 601–609.

Goldman, L. (2019, November 22). Depression: What it is, symptoms, causes, treatment, types, and more (T. J. Legg, Ed.). Retrieved from https://www.medicalnewstoday.com/articles/8933

How SSRIs work. (n.d.). Retrieved October 1, 2020, from https://www.ocduk.org/overcoming-ocd/medication/how-ssri-work/

Lim, G. Y., Tam, W. W., Lu, Y., Ho, C. S., Zhang, M. W., & Ho, R. C. (2018). Prevalence of Depression in the Community from 30 Countries between 1994 and 2014. Scientific Reports, 8(1), 2861.

Rossi, A., Barraco, A., & Donda, P. (2004). Fluoxetine: A review on evidence based medicine. Annals of General Hospital Psychiatry, 3(1), 2.

Steffens, D., Krishnan, K., et al. (1997). Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta-analysis. In Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews. Centre for Reviews and Dissemination.

Wang, J., Wu, X., et al. (2017). Prevalence of depression and depressive symptoms among outpatients: A systematic review and meta-analysis. BMJ Open, 7(8), e017173.

Wenthur, C. J., Bennett, M. R., & Lindsley, C. W. (2014). Classics in Chemical Neuroscience: Fluoxetine (Prozac). ACS Chemical Neuroscience, 5(1), 14–23.

Resources (as provided by the Govt. of Canada website):

Crisis Services Canada
Available to all Canadians seeking support. Visit Crisis Services Canada for the distress centres and crisis organizations nearest you.
If you or someone you know is thinking about suicide, call the Canada Suicide Prevention Service at 1-833-456-4566 (24/7) or text 45645 (4 pm to 12 am ET).

Kids Help Phone
Call 1-800-668-6868 (toll-free) or text CONNECT to 686868.
Available 24 hours a day to Canadians aged 5 to 29 who want confidential and anonymous care from professional counsellors.
Download the Always There app for additional support or access the Kids Help Phone website.

Hope for Wellness Help Line
Call 1-855-242-3310 (toll-free) or connect to the online Hope for Wellness chat.
Available to all Indigenous peoples across Canada who need immediate crisis intervention. Experienced and culturally sensitive helpline counsellors can help if you want to talk or are distressed.
Telephone and online counselling are available in English and French. On request, telephone counselling is also available in Cree, Ojibway and Inuktitut.

Music Credit
► Music Credit: LAKEY INSPIRED
Track Name: "Blue Boi"
Music By: LAKEY INSPIRED @ https://soundcloud.com/lakeyinspired
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