Edit: @HansHaupt has found a much easier solution and posted it in the comments. You just need to turn off Voice Isolation in the mic settings in the top toolbar and that should fix the issue.

Original:
In this video, I'll walk you through a simple workaround to overcome audio distortion problems when using the Elgato HD60X with OBS Studio. We'll be leveraging QuickTime to record and then stream via OBS Studio. Then you can use OBS Studio to stream the QuickTime screen.

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